Tivoxen 1.34 mg (Tivozanib)

Description

Tivoxen 1.34 mg is a lozenge that comes with a tradition of Tivozanib, an oral diurnal tyrosine kinase asset( TKI) used primarily for the treatment of renal cell melanoma( RCC), which is order cancer. It has been shown to work in cases who were treated ahead and is considered to have a fairly tolerable side effect profile. Understanding how Tivoxen works, how to duly use it properly, and associated preventives can help cases and caregivers with opinions about cancer treatment.

What is Tivoxen 1.34 mg?

Tivozanib, a highly selective agonist of vascular endothelial growth factor receptors (VEGFR), is marketed as Tivoxen 1.34 mg. It blocks signals that encourage the growth of blood vessels that supply excrescences through the inhibition of VEGFR- 1, VEGFR- 2, and VEGFR- 3. This helps minimize or indeed stop cancer growth.

Tivoxen is particularly indicated in metastatic renal cell melanoma( RCC) adult cases, especially where the condition has reenacted after original treatment. It may be used as a monotherapy or part of combination cancer remedy depending on the clinical script.

How to Use Tivoxen 1.34 mg?

Tivoxen is administered orally as a capsule. Take the drug with or without food, daily. Do not bite, crack, or crush the capsule; instead, swallow it whole with water.

Cases are needed to follow a regular dosing schedule and take the 21- days- on and 7- days- off authority( i.e., 3 weeks of diurnal treatment and 1 week out) unless advised else by a medical guru. It’s preferable to avoid missing a cure, but if one has been missed and nearly time for the coming is at hand, skip the missed one — noway double the cure given to make up for the one missed.

Dosage and Administration

The recommended cure of Tivoxen is 1.34 mg daily for 21 consecutive days with an interval of 7 days of rest, being a 28- day treatment cycle. This type of dosing is designed to reduce the threat of side effects but maintain the efficacity of the medicine.

Reduce the lozenge in cases with liver complaint or severe side effects. Physicians should drop the cure or intrude remedy grounded on patient response and forbearance. A croaker should be consulted before changing lozenge authority.

How Does It Work?

Tivozanib, the active component of Tivoxen, acts against VEGF receptors, which are honored to initiate new growth of blood vessels in cancer( angiogenesis). By inhibiting the receptors, Tivozanib cuts off the blood force to the cancer, depriving it of oxygen and nutrients, and therefore checks its development and growth.

This picky exertion makes it particularly useful for treating renal cell melanoma, a veritably vascular cancer. Therefore, it generally has smaller off-target side effects than less specific TKIs.

Tivoxen 1.34 mg for Side Effects

Like all specifics for cancer, Tivoxen 1.34 mg has side effects. They are

Fatigue

High blood pressure( hypertension)

Diarrhea

Loss of appetite

Weight loss

Hoarseness

Hand- bottom pattern( palmar- plantar erythrodysesthesia)

Milder but lower frequent side effects are

Cardiac issues( e.g., cardiac failure)

Hepatic insufficiency

Thromboembolic events( blood clots)

Routine blood pressure monitoring, liver function tests, and electrocardiograms( ECGs) must be done in cases on treatment.

Warnings and Precautions

Tivoxen should be used cautiously in cases with

Cardiovascular complaint threat of hypertension and cardiac events necessitates monitoring and implicit antihypertensive remedy.

dropped liver function. Lozenge adaptation should be made according to liver function.

Threat of bleeding diseases or thromboembolism

It’s also judicious to avoid surgery while taking Tivozanib, as it can intrude with crack mending. It should be discontinued at least 24 days before any future surgery and proceeded only after complete recovery, as assessed by a croaker.

Pregnancy and Lactation

Tivoxen 1.34 mg mustn’t be administered during gestation as it’s poisonous to fetal development. It has been shown in beast studies to be embryotoxic and teratogenic. parturition eventuality, ladies must use effective contraception during treatment and for a minimum of one month after the treatment has been discontinued.

No data on the excretion of Tivozanib into mortal milk are available, but due to implicit adverse effects on a lactating child, lactation isn’t recommended during treatment with this drug and for some weeks following remedy termination.

Tivoxen 1.34 mg for Drug Interaction

Interaction with other medicines, especially those affecting CYP3A4 enzymes, e.g.,

Rifampin

Carbamazepine

Phenytoin

Ketoconazole

Cases should advise their medical interpreters of all the medicines, salutary supplements, and herbal medications they’re taking. Grapefruit juice, a known CYP3A4 asset, should also be avoided during treatment.

Storage

The capsules of Tivoxen should be kept in the original quilting at room temperature( 20 °C to 25 °C or 68 °F to 77 °F). Avoid exposure to humidity, direct sun, and heat sources. Keep the medicine out of the reach of children and domestic creatures.

Do not use the medicine beyond the expiry date, and get relieve of unused or expired capsules as per original pharmaceutical disposal procedures.

Conclusion

Tivoxen 1.34 mg (Tivozanib) is a salutary treatment option for advanced renal cell melanoma cases. Because of its selectivity of medium and respectable side effect profile, it’s an encouraging medicine in the remedial armamentarium of oncology. Like all potent medicines, still, it requires strict dosing compliance, regular monitoring, and open communication with healthcare professionals. Always consult your croaker or druggist before starting or stopping any drug, and report any unusual side effects instantly.